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PTCH1 biomarker and colorectal cancer

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What is the PTCH1 biomarker?

The PTCH1 gene is a tumor suppressor gene that contains the instructions for making the patched-1 protein. The gene encodes a member of the patched family of proteins and is a component of the hedgehog signaling pathway.

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How common is the PTCH1 mutation?

PTCH1 is altered in approximately 4 percent of colorectal cancer patients.

Some mutations are acquired during a person's lifetime and are present only in certain cells. These genetic changes, called somatic mutations, are not inherited.

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What happens if I have the PTCH1 mutation?

Although there are no FDA approved therapies targeting PTCH1 mutations to date, there is a clinical trial investigating the efficacy of a potential treatment in cancer patients with PTCH1 Loss of Function mutations.

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