National Nonprofit the Colorectal Cancer Alliance Provides Funding to Help Fill Urgent Colon and Rectal Cancer Research Needs

National nonprofit Colorectal Cancer Alliance is providing a total of $625,000 in grants to four researchers, including one advancing personalized treatment options for rectal cancer patients and three seeking to understand the root cause of rising colorectal cancer rates in patients under age 50.
Grant recipients include:
With this funding announced today, grant awardee Dr. J. Joshua Smith intends to open avenues to developing innovative, personalized treatments for rectal cancer by creating better models for experimentation.
Nearly a third of colorectal cancer cases originate in the rectum, and the total number of cases is increasing sharply among young people. Personalized or precision treatments can improve outcomes for rectal cancer patients who have exhausted conventional treatment options.
Today's rectal cancer models are often derived from colon cancer specimens, which are different from rectal cancer specimens, or other methods that do not represent rectal cancer well.
“Once successful, Dr. Smith will fill a desperate research need—disease models for individual rectal cancers—which would provide the foundation for developing and optimizing precision treatments for patients,” said Dr. Ronit Yarden, director of medical affairs at the Alliance.
Funding provided by the Alliance is part of the organization’s continued efforts to invest $10 million in critical and innovative research.
The Colorectal Cancer Alliance is now accepting applications for its prevention research grants. The application deadline is 11:59 p.m., Monday, March 18, 2019.
The Alliance's Project Cure CRC announces $1.3 million in new research grants — bringing total funding to nearly $12 million — to drive breakthroughs in colorectal cancer care and address critical research gaps.
The 2025 ASCO Annual Meeting featured several important studies that could change how colorectal cancer is treated, including a pivotal study for BRAF V600E patients.