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The leading national nonprofit to end colorectal cancer, the Colorectal Cancer Alliance (Alliance), today announced a transformative research investment strategy to guide the field and its own $30 million in research funding over the next five years.
A white paper documents the analysis and conclusions behind the Alliance’s reimagined strategy, including a comprehensive landscape and return on investment assessment, as well as input from dozens of experts and thought leaders. Three overarching themes for research investment emerged. Each is detailed further in the paper.
“Novel treatments, advancements in screening, and a focus on equity are improving colorectal cancer survivorship, but there is still a tremendous unmet need,” said Andrea Goodman, the Alliance’s vice president of patient support and research strategy. “Colorectal cancer is not getting the funding or attention it deserves, with virtually no change in government funding between 2006 and 2018. The Alliance will not accept this. Our $30 million research commitment and this collaboratively developed plan will jumpstart immediate learnings and ultimately save lives sooner.”
The categories of research priorities identified include:
The Alliance has already invested nearly $5 million in colorectal cancer research, including nearly $3 million as early-stage grants to innovative researchers. Highlighting the return on its investments, two grantees supported with $400,000 of funding from the Alliance have gone on to receive more than $6.5 million in federal research funding.
Colorectal cancer, the second deadliest cancer in the United States among men and women combined, will be diagnosed 149,500 times this year, according to estimates from the American Cancer Society. As many as 52,980 patients will die.
The Alliance’s next funding opportunity for colorectal cancer researchers will open in spring 2022.
About the Colorectal Cancer Alliance
The Colorectal Cancer Alliance is a national nonprofit committed to ending colorectal cancer. Working with our nation of passionate allies, we diligently support the needs of patients and families, caregivers, and survivors; eagerly raise awareness of preventive screening; and continually strive to fund critical research. As allies in the struggle, we are fiercely determined to end colorectal cancer within our lifetime. For more information, visit colorectalcancer.org.

A first-of-its-kind trial platform in the colorectal cancer space, Project Cure CRC’s KLEOS is being driven by the Colorectal Cancer Alliance, the leading nonprofit dedicated to ending the disease, in collaboration with GCAR, a pioneer in the design and implementation of innovative clinical trials.

The Colorectal Cancer Alliance will present three poster sessions and deliver an oral presentation at the American Association for Cancer Research Annual Meeting 2026.

hrough Project Cure CRC, the Alliance is fueling bold, early-stage research with the potential to transform colorectal cancer treatment. Dr. Lisa Mielke’s groundbreaking work explores how the gut’s immune system and nerve signaling influence cancer growth—opening the door to new therapeutic approaches, including repurposed existing drugs. This is what’s possible when promising ideas get the support they need to move forward.